Gran Madre di Dio is a cardinal's titular church in Rome. Its current holder is Angelo Bagnasco, Archbishop of Genoa, who was created a cardinal on 24 November 2007. The church was established as a titular church in 1965. The monumental temple was built by Pope Pius XI in 1931, in memory of the celebrations held to commemorate the 1,500 anniversary of the Council of Ephesus, which established the dogma of the divine motherhood and her perpetual virginity of Mary, in the patristic tradition and popular devotion since From the Church. It was built between 1931 and 1933 by architect Cesare Bazzani, built by Clemente Busiri Vici. It is the seat of the parish of the same name, erected by Pius XI on 1 December 1933, the year of Jubilee extraordinary redemption, in the Apostolic Constitution "Quo perennius".